Prostate Specific Antigen - Total
Why do we do this test?
PSA is measured to screen for carcinoma prostate, to assist in the diagnosis, to assess the response to therapy and in the long term follow up to detect recurrences.
PSA is a protein produced by both cancerous and non- cancerous tissues in the prostate.
High levels of PSA are found in prostatic cancer. But marginally high levels are found in benign prostatic hyperplasia (BPH) and in elderly. Interpretation of your PSA value therefore should be done with consultation with your doctor.
Specimen Type
Serum, Plasma (EDTA), Plasma (Li Heparin)
Instructions for specimen collection & Patient preparation
Specimen transportation & Processing
Transport separated serum/plasma in ice (2-8C). If prolonged storage store
at -20 C.
Specimen storage & stability
Separate serum as soon as possible.
For prolonged storage keep frozen at -20C. If analysis within 5 days stable at 0C.
Specimen storage duration
Reference Intervals & Target Values
<40 yrs <1.3 ng/mL
41 - 50 yrs <2.0 ng/mL
51 – 60 yrs <3.3 ng/mL
61 – 70 yrs <4.0 ng/mL
>70 yrs <4.5 ng/mL
Critical Limits
Possible Pre-analytical Errors
Gross Haemalysis
Possible Analytical Errors
Insufficient serum/plasma volume, Air bubbles, Fibrin clots.
Available Government Laboratories
Apeksha Hospital, National Hospital Sri Lanka, Medical Research Institute, National Hospital Kandy, Teaching Hospital Jaffna, North Colombo Teaching Hospital, Karapitiya Teaching Hospital
Recommended turnaround time
1 - 2 days

Test Method


1. Daniel W.Chan, Stewart Sell; Tumour Markers. Burtis CA, Ashwood ER. Tietz Text Book of Clinical Chemistry,3rd edition, USA, Elsevier Saunders 1999, 722-749

Last Updated : 2020-09-14 05:07:37






College of Chemical Pathologists of Sri Lanka

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