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COLLEGE OF CHEMICAL PATHOLOGISTS

OF SRI LANKA

 
Urine organic acid (Qualitative) print
Synonyms
Why do we do this test?
Diagnosis of inborn errors of metabolism especially when organic aciduria is suspected
Specimen Type
Urine (spot/ timed collection)
Instructions for specimen collection & Patient preparation
Urine ideally is collected at the time of acute illness. If patient is asymptomatic a random urine sample is appropriate.
Collect to a clean container without preservatives
Specimen transportation & Processing
Specimen preferably transported frozen
Specimen storage & stability
Freeze as soon as possible at -20 °C
Specimen storage duration
Stable at -20° C or lower for several years
Reference Intervals & Target Values
Since this is a qualitative test an interpretive report will be provided
Critical Limits
Not applicable
Possible Pre-analytical Errors
Diet (including TPN, gelatin, medium-chain triglyceride oil supplements, infant formula, ketogenic diet)
Medications (valproate, levetiracetam, aspirin, benzoic acid, ibuprofen, acetaminophen )
Bacterial contamination due to improper handling of samples
Informative profiles may not always be detected in disorders where the excretion of diagnostic metabolites is a reflection of the residual activity of the defective enzyme, the dietary load of precursors, and the anabolic/catabolic status of a patient.
Possible Analytical Errors
Analyte co-elution
Contaminants
Extraction efficiency
Incomplete derivatization
Available Government Laboratories
Lady Ridgeway Hospital for Children, Department of Chemical Pathology
Recommended turnaround time
Minimum 1 week
(If the analysis is urgent contact the Department of Chemical Pathology, LRH with clinician recommendation)
Maximum 3 months

Test Method
Gas Chromatography Mass Spectrometry

Documentation

References

Last Updated : 2020-09-13 21:43:32

 

 

 

 

College of Chemical Pathologists of Sri Lanka

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Hotline : +94 76 7044871
Email :
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